Incurin Can Cause Vulva Swelling in Dogs: A Known Side Effect

Incurin Can Cause Vulva Swelling in Dogs: A Known Side Effect

PLEASE NOTE: Melody is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to

This post contains affiliate links. When you click on these links and make a purchase, I earn a percentage of the sale which allows me to keep providing you great content for free on this website.

Incurin can cause vulva swelling in dogs but usually only at the maximum dose
Incurin can cause vulva swelling in dogs but usually only at the maximum dose

Three weeks ago, Misha started taking Incurin (Estriol) for urine leakage.  Incurin is a synthetic hormone that has less side effects than DES and is usually more effective than other medications used for this female urine leakage.   With Incurin, you start your dog on the maximum dose of two pills every day for two weeks.  Then, you reduce it to one pill a day for 7 days. You reduce the amount each week (always keeping your dog on any dose for at least a week) until you find the lowest amount that is effective.

Misha finished the first two weeks and the results have been fantastic.  On Proin and DES she still dribbled. DES was given once a week.  By the sixth day, she usually had an accident.  With Incurin, she has not dribbled or peed in the house at all. It is really effective in controlling here problem.

Unfortunately, she is experiencing one of the known side effects.  On the twelfth day, I was walking behind her and noticed something was different about her back end..  She seemed jiggly in the lower part of her butt.  I realized she was swollen.  I did some research and found out that Incurin can cause swelling of the vulva at the maximum dose.

I emailed our veterinarian to confirm this and to see what we should do next.  She wanted photographs to see how bad the swelling was.  Simple, right?   You ever notice how much control dogs have over their tails even when those tails are cropped?  Misha was on to me.  Every time I came near with the camera, she folded her tail downward so I couldn’t see anything. She refused to show me her tummy for a underneath view.

I did get a couple usable photos.  I’ll spare you those.  Instead, here is my dog trying to escape the paparrazzi.

My Jack Russell Terrier trying to escape my camera
My Jack Russell Terrier trying to escape my camera

Normally, they recommend taking your dog off the medication for a week, then restarting every other day.  Because the swelling wasn’t bad, our veterinarian decided to switch Misha to a pill every other day immediately.  We’ll have to try something else if the swelling doesn’t go away.

She has been on that dose for one week. So far, no urine leakage. The vulva is still a little swollen but it isn’t as bad as that first jiggly day. Hopefully, in a week or two she will be back to normal. The research shows the swelling does not persist at lower doses.

If you’ve recently started your dog on Incurin, keep an eye out for this side effect. You may need to adjust the dosage, but be sure to talk to your veterinarian first as another issue might be at play.

Leave it to Misha to be one of the 4.3% with vulva swelling! At least she doesn’t seem to be bothered by it. If this doesn’t work we may be buying doggie diapers.

Thanks for this PAWSit Hop, Ruth!


6 thoughts on “Incurin Can Cause Vulva Swelling in Dogs: A Known Side Effect

  1. I was not familiar with this urinary problem in dogs and the side effects of the medication for treatment. Like you, I sure hope all goes well with Misha and you won’t need to buy dog diapers!

    1. Thanks Ruth! Unfortunately, any medication can have side effects. At least she isn’t in 24 hour anxiety attack mode like with Proin. The swelling isn’t bothering her, so I am willing to wait it out to see if it disappears in a week or two. She’s doing really well on this drug. It’s the most effective of the three she has tried.

  2. I knew dogs can have urine problems when older or had many litters. I did not know of any side effects.

    1. Sandy, thanks for your comments! Not only can they have problems in old age, but female dogs can have bladder problems like women of a certain age. It can be really frustrating to deal with.

  3. Is the swelling harmful to the dog? Mine is QUITE swollen with 1 Incurin tablet per day AND Proin at night, but the combination of both has seemed to work. I have not tried using the Incurin every other day. Scared. The past leakage has been so bad and had our house smelling awful!

    1. NL, Thanks for your comment! First off, I’m not a veterinarian, so I can’t speak to whether the swelling is harmful to your dog.

      What I was told was the swelling can be temporary. It may make your dog uncomfortable. So, it may be possible to move to 1 pill every other day, then if needed go back to 1 pill every day. I would discuss this with your dog’s vet.

      I do understand what you are going through. My dog’s leakage started as tiny dribbles, but within a couple months she was having accident in the house and leaving urine behind when she sat on my lap.

      We tried Proin which worked great for my previous dog, but Misha developed the anxiety issues associated with it. We tried DES, but it affected her blood cell counts. Incurin (Estriol) has been a blessing.

      I have had to adjust her dose from time to time. She was on one dose every 3 days during autumn. But, in February we had many days of rain and she began to dribble again (I don’t think she wanted to go outside and get wet). I’ve moved her back to every other day for now.

      I hope the Incurin/Proin combination will be just what your dog needs! Do check with the vet on the swelling. It may even be possible to go to 1/2 tablet a day. Good luck! I know how frustrating this is.

Leave a Reply

Your email address will not be published. Required fields are marked *